Basic Science Focus Forum - Session I - Wednesday, October 15
Current Concepts in Open Fracture Wound Management
Moderators: Emil H. Schemitsch, MD & Mohit Bhandari, MD
Wed., 10/15/08 BSFF, Paper #1, 8:55 am OTA-2008
A Comparison of Sterile and Potable Water Irrigation in a Porcine Open Fracture Model
LCDR Robert J. Gaines, MC, USN (n); LCDR Craig Randall, MC USN (n);
CAPT Marlene DeMaio, MC USN (n);
Department of Orthopaedics, Naval Medical Center Portsmouth, Portsmouth, Virginia, USA
Wed., 10/15/08 BSFF, Paper #2, 9:01 am OTA-2008
Locally Administered Antibiotics in Extremity Wounds
Joanna G. Branstetter, MD1 (n); Stephanie R. Jackson2 (n); Kelly Richelsoph, PhD2 (n);
Warren O. Haggard, PhD2 (n); Joseph C. Wenke1 (n);
1US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA;
2Department of Biomedical Engineering, University of Memphis, Memphis, Tennessee, USA
Wed., 10/15/08 BSFF, Paper #3, 9:07 am OTA-2008
A Skeletal Drug Delivery System: Gentamicin- and Vancomycin-Incorporated Calcium Phosphate Cement
Sahil Jalota, PhD1 (a-Skeletal Kinetics); Yvette S. McCarter2 (n);
B. Hudson Berrey, Jr., MD2 (a-Skeletal Kinetics); David C. Delaney1 (a-Skeletal Kinetics);
Duran N. Yetkinler MD1 (a-Skeletal Kinetics);
1Skeletal Kinetics, Cupertino, California, USA;
2University of Florida, College of Medicine-Jacksonville, Jacksonville, Florida, USA
James R. Romanowski, MD1 (a-OTA Research Grant);
Michael T. Archdeacon, MD, MSc1 (e-Stryker); Paula S. Mobberley-Schuman, MSc2 (n);
Alison A. Weiss, PhD2 (n);
1Department of Orthopaedic Surgery, University of Cincinnati, Cincinnati, Ohio, USA
2Department of Molecular Genetics, Biochemistry and Microbiology,
University of Cincinnati, Cincinnati, Ohio, USA
Wed., 10/15/08 BSFF, Paper #5, 11:05 am OTA-2008
5-Lipoxygenase Is a Negative Regulator of Fracture Repair
Jessica A. Cottrell, PhD (a-UMDNJ-NJMS); J. Patrick O’Connor, PhD (a-UMDNJ-NJMS);
University of Medicine and Dentistry of New Jersey, New Jersey Medical School,
Newark, New Jersey, USA
Wed., 10/15/08 BSFF, Paper #6, 11:11 am OTA-2008
Role of Oxygen in Fracture Repair
Chuanyong Lu, MD1 (n); Arjun Sinha1 (n); Mark Rollins, MD2 (n);
Theodore Miclau, III, MD1 (n); Ralph S. Marcucio, PhD1 (a-NIH);
1Department of Orthopaedic Surgery, University of California at San Francisco,
San Francisco, California, USA;
2Department of Anesthesia and Perioperative Care,
University of California at San Francisco, San Francisco, California, USA
Wed., 10/15/08 BSFF, Paper #7, 11:17 am OTA-2008
Megan Lynne Young, MD1 (a-Zelos Therapeutics); Rachel Fontaine2 (a-Zelos Therapeutics);
Zachary Mason2 (a-Zelos Therapeutics); Gavin Bishop, MD1 (a-Zelos Therapeutics);
Louis Gerstenfeld, PhD1 (a-Zelos Therapeutics); Elise Morgan, PhD2 (a-Zelos Therapeutics);
Thomas A. Einhorn, MD1 (a,e-Zelos Therapeutics);
1Boston University Medical Center, Boston, Massachusetts, USA;
2Boston University College of Engineering Aerospace and Mechanical Engineering,
Boston University, Boston, Massachusetts, USA
Wed., 10/15/08 BSFF, Paper #8, 11:29 am OTA-2008
The Effect of rhBMP-7 on Fracture Healing in an Ischemic Environment
Chuanyong Lu, MD (n); Zhiqing Xing, MD (n); Theodore Miclau, III, MD (n);
Ralph S. Marcucio, PhD (a-NIH);
Department of Orthopaedic Surgery, University of California at San Francisco,
San Francisco, California, USA
Wed., 10/15/08 BSFF, Paper #9, 11:35 am OTA-2008
Temporal and Spatial Dynamics of Sclerostin Expression during Murine
Fracture Repair Damian C. Genetos, PhD1 (n); Safdar Khan, MD2 (n); Savvas E. Papanicolaou2 (n);
David P. Fyhrie, PhD2 (n); Mark A. Lee, MD2 (a-UC Davis Department of Orthopaedic Surgery);
1Biomedical Engineering, University of California Davis, Davis, California, USA;
2Department of Orthopaedic Surgery, University of California Davis, Davis, California, USA
Wed., 10/15/08 BSFF, Paper #10, 11:41 am OTA-2008
Bone Repair Is Affected by the Age and Composition of Inflammatory Cells at the Fracture Site
Zhiqing Xing, MD (n); Chuanyong Lu, MD (n); Diane Hu, MD (n);
Theodore Miclau, III, MD (n); Ralph S. Marcucio, PhD (a-NIH);
Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California, USA
Basic Science Focus Forum - Session III - Wednesday, October 15
Biomechanics of Fracture Fixation
Moderators: Steven A. Olson, MD & J. Lawrence Marsh, MD
Wed., 10/15/08 BSFF, Paper #11, 2:20 pm OTA-2008
A Biomechanical Comparison of Three Distal Humerus Fixation Methods
Veerabhadra Reddy, MD1 (a-Stryker; b-Accumed, Synthes); Yupeng Ren, MS2 (n);
Navjot Kohli, MD3 (n); Robert Matlock, MD4 (n); Li-Qun Zhang, PhD2 (n);
Bradley Merk, MD3 (a-Stryker; b-Accumed, Synthes);
1OrthoCarolina Foot and Ankle Institute, Charlotte, North Carolina, USA;
2Rehabilitation Institute of Chicago, Chicago, Illinois, USA;
3Northwestern University, Feinberg School of Medicine, Department of Orthopedic Surgery,Chicago, Illinois, USA;
4M and M Orthopaedics, Naperville, Illinois, USA
Wed., 10/15/08 BSFF, Paper #12, 2:26 pm OTA-2008
Joshua B. Catanzarite, MS1 (n); Lisa C. Benson PhD1 (a-Synthes);
Kyle J. Jeray, MD2 (a,b-Synthes; e-Zimmer); Stephanie L. Tanner2 (n);
1Clemson University, Clemson, South Carolina, USA;
2Greenville Memorial Hospital, Greenville, South Carolina, USA
Wed., 10/15/08 BSFF, Paper #13, 2:32 pm OTA-2008
Comparison of Fixation of Small Fragment and Mini-Fragment Lag Screws in an Osteoporotic Bone Model
Samir Mehta, MD1 (n); Daphne M. Beingessner, Msc, MD, FRCSC2 (a-Synthes, Zimmer);
1University of Pennsylvania, Philadelphia, Pennsylvania, USA;
2Harborview Medical Center, Seattle, Washington, USA
Wed., 10/15/08 BSFF, Paper #14, 2:38 pm OTA-2008
Christopher Jones, MD1 (n); W. Baione2 (n); Gregory A. Zych, DO1 (n);
Edward L. Milne1 (a-Nutek Orthopaedics); David Kaimrajh2 (a-Nutek Orthopaedics);
Loren L. Latta, PhD1,2 (a-Nutek Orthopaedics, Inc.);
1Department of Orthopaedics, University of Miami, Miami, Florida, USA;
2Department of Biomechanical Engineering, University of Miami, Miami, Florida, USA
San Francisco, California, USA
Wed., 10/15/08 BSFF, Paper #15, 4:45 pm OTA-2008
Thaddeus P. Thomas, MS1,2 (n);
Christopher J. Van Hofwegen, MD1 (a-DePuy, Smith + Nephew, NIH, OREF);
Donald D. Anderson, PhD1,2 (a-AO Foundation, Switzerland, NIH, OTA);
J. Lawrence Marsh, MD1 (a-NIH, The Arthritis Foundation; e-Biomet);
Thomas D. Brown, PhD1,2 (a-NIH, The Arthritis Foundation);
1Department of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, Iowa, USA;
2Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa, USA
Wed., 10/15/08 BSFF, Paper #16, 4:51 pm OTA-2008
Joseph Borrelli, Jr., MD1 (a-AO, Biomet, KCI, Sanofi-Aventis; Smith + Nephew, Stryker,
Synthes, Inc., Wyeth, Zimmer; a,e-Wright Medical Technology, Inc.; e-Pfizer);
Melissa Zaege, BS2 (n); Matthew Silva, PhD2 (n);
1University of Texas Southwestern Medical Center, Dallas, Texas, USA;
2Washington University School of Medicine, St. Louis, Missouri, USA
Wed., 10/15/08 BSFF, Paper #17, 4:57 pm OTA-2008
Cecilia Pascual Garrido, MD (a-Rush); Arnavaz Hakimiyan (a-Rush);
Lev Rappaport, MD (a-Rush); Vivek Shekhawat (a-Rush); Carol Pacione (a-Rush);
Markus Wimmer, PhD (a-Rush); Ted Oegema, PhD (a-Rush);
Susan Chubinskaya, PhD (a-Rush);
Rush University Medical Center, Chicago, Illinois, USA
Wed., 10/15/08 BSFF, Paper #18, 5:03 pm OTA-2008
Donald D. Anderson, PhD1,2 (a-AO Foundation, Switzerland, NIH, OTA); Wendy Li, MS1,2 (n);
Christopher J. Van Hofwegen, MD (a-DePuy, Smith + Nephew, NIH, OREF);
J. Lawrence Marsh, MD1 (a-NIH, The Arthritis Foundation; e-Biomet);
Thomas D. Brown, PhD1,2 (a-NIH, The Arthritis Foundation);
1Departments of Orthopaedics and Rehabilitation, The University of Iowa, Iowa City, Iowa, USA;
2Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa, USA
Thurs., 10/16/08 BSFF, Paper #19, 8:50 am OTA-2008
Eric A. Breitbart, MD (n); Vikrant Azad, MD (n); Sloane Yeh, MD (n); Loay Al-Zube, MD (n);
Sheldon S. Lin, MD (a-Biomimetic, DePuy, A Johnson & Johnson Company; b,e-Tornier);
University of Medicine and Dentistry of New Jersey, New Jersey Medical School,
Newark, New Jersey, USA
Thurs., 10/16/08 BSFF, Paper #20, 8:56 am OTA-2008
Mesenchymal Stem Cell (MSC) Augmentation Enhances Allograft Incorporation in a Diabetic Rat Model
Eric A. Breitbart, BS1 (n); Sharonda Meade, MD1 (n); Sloane Yeh, MD1 (n);
Loay Al-Zube, PhD1 (n); Vikrant Azad, MD1 (n); Yee-Shaun Lee, PhD2 (n);
Treena Livingston Arinzeh, PhD2 (n); Sheldon S. Lin, MD1 (a-Biomimetic, DePuy, A Johnson & Johnson Company; b,e-Tornier);
1Department of Orthopaedics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, USA;
2Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA
Thurs., 10/16/08 BSFF, Paper #21, 9:02 am OTA-2008
Rena L. Stewart, MD (a-Synthes, Wyeth, OTA);
James P. Stannard, MD (a-Smith + Nephew, Synthes);
David A. Volgas, MD (a-Biomet (Interport-Cross), Smith + Nephew, Synthes, Pfizer);
Irshad H. Chaudry, PhD (n); Justin N. Duke, MD (n); Jorge E. Alonso, MD (e-Synthes);
University of Alabama at Birmingham, Birmingham, Alabama, USA
Thurs., 10/16/08 BSFF, Paper #22, 9:14 am OTA-2008
Repair of Segmental Bone Gap Using Multipotent Adult Stem Cells (MASCs)
Timothy Achor, MD (a-New York Medical College);
Casey Chafe, BA (a-New York Medical College);
David E. Asprinio, MD (a-New York Medical College);
Paul A. Lucas, PhD (a-New York Medical College);
New York Medical College, Valhalla, New York, US
Thurs., 10/16/08 BSFF, Paper #23, 9:20 am OTA-2008
Tissue-Engineered Reconstruction of Massive Femoral Defects Treated with Teriparatide (rhPTH(1-34))
Justin A. Jacobson, MD1 (n) Laura Yanuso1,2 (n) Tulin Dadali1,2 (a-Coulter Foundation Grant)
David G. Reynolds1,2 (a-NIH Grant); Susan V. Bukata, MD1 (a-NIH Grant)
J. Edward Puzas, PhD1 (a-Zimmer; b-Eli Lilly, Procter & Gamble; b,e-Merck, Norvartis);
Michael Zuscik, PhD1 (n);
Randy N. Rosier, MD, PhD1 (a-NIH Grants, Coulter Foundation Grant)
Regis J. O’Keefe MD, PhD1 (a-NIH Grants) Edward M. Schwarz, PhD1 (a-MTF, NIH);
Hani A. Awad, PhD1,2 (a-NIH Grants);
1Department of Orthopaedics and Rehabilitation, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA;
2Biomedical Engineering, University of Rochester, Rochester, New York, USA
Thurs., 10/16/08 BSFF, Paper #24, 9:26 am OTA-2008
Loay A. Al-Zube, PhD1 (n); Eric A. Breitbart, BS1 (n);
J. Patrick O’Connor, PhD1 (a-UMDNJ-NJMS); J. Russell Parsons, PhD1 (n);
Gino Bradica, PhD2 (e-Kensey Nash Corporation);
Charles E. Hart PhD3 (d,e-Biomimetic Therapeutics);
Sheldon S. Lin, MD1 (a-Biomimetic, DePuy, A Johnson & Johnson Company; b,e-Tornier);
1University of Medicine and Dentistry of New Jersey, New Jersey Medical School and Graduate
School of Biomedical Sciences, Newark, New Jersey, USA;
2Kensey Nash Corporation, Exton, Pennsylvania, USA;
3BioMimetic Therapeutics, Inc., Franklin, Tennessee, USA
If noted, the author indicates something of value received. The codes are identified as a-research or institutional support; b-miscellaneous funding; c-royalties; d-stock options; e-consultant or employee; n-no conflicts disclosed, and *disclosure not available at time of printing.
• The FDA has not cleared this drug and/or medical device for the use described in this presentation (i.e., the drug or medical device is being discussed for an “off label” use). ◆FDA information not available at time of printing. Δ OTA Grant.