Session VII - Basic Science


Moderator: Theodore Miclau, III, MD & Emil H. Schemitsch, MD


Fri., 10/19/07 Basic Science, Paper #38, 4:05 pm OTA-2007

Δ The Role of Parathyroid Hormone in the Mechanosensitivity of Fracture Healing

Michael J. Gardner, MD1; Marjolein C. H. van der Meulen, PhD1,2; Joshua Carson, MD1; Jonathan Zelken, MD1; Benjamin F. Ricciardi, BA1; Timothy M. Wright, PhD1;
Joseph M. Lane, MD1; Mathias P. Bostrom, MD1 (all authors: a-OTA/Stryker, OREF Grant);
1Hospital for Special Surgery, New York, New York, USA;
2Cornell University, Ithaca, New York, USA


Fri., 10/19/07 Basic Science, Paper #39, 4:11 pm OTA-2007

The Role of Leptin in the Local Control of Fracture Healing

Safdar N. Khan, MD1 (n); Mark A. Lee, MD1 (n); Grayson DuRaine, BS1 (n);
Jennifer Fung, BS2 (n); Douglas Rowland, PhD2 (n); A. Hari Reddi, PhD1 (n);
1Department of Orthopaedic Surgery, University of California, Davis, California, USA;
2Center for Molecular and Genomic Imaging, University of California, Davis, California, USA


Fri., 10/19/07 Basic Science, Paper #40, 4:17 pm OTA-2007

Parathyroid Hormone and Alendronate Improve Osteotomy Healing in an Osteoporotic Rat Model

Jose B. Toro, MD (n); Andy Tomin, BS (n); Kathleen Meyers MS (n); Brett Shore, MD (n);
Margareth Lauerman, MD (n); Paul Issack, MD, PhD (n); Joseph Lane, MD (n);
Hospital for Special Surgery, New York, New York, USA


Fri., 10/19/07 Basic Science, Paper #41, 4:30 pm OTA-2007

Growth Factor Release following Femoral Nailing

Peter V. Giannoudis, MD1 (n); Ippokratis Pountos, MD1 (n); John Morley, MD1 (n);
Sarah Perry, MD2 (n); Hans-Christoph Pape, MD2 (n);
1Academic Department of Trauma & Orthopaedic Surgery, School of Medicine, University of Leeds, United Kingdom;
2University of Pittsburgh, Pittsburgh, Pennsylvania, USA


Fri., 10/19/07 Basic Science, Paper #42, 4:36 pm OTA-2007

Cigarette Smoking Is Associated with Lower Concentration of Bone Marrow Mesenchymal Stem Cells

Shaul Beyth, MD (a-Hadassah); Anat Daskal, MSc (n); Amal Khoury, MD (n);
Rami Mosheiff, MD (n); Meir Liebergall, MD (a-Teva);
Hadassah University Medical Center, Jerusalem, Israel


Fri., 10/19/07 Basic Science, Paper #43, 4:48 pm OTA-2007

How Much Does the Addition of Locked Screws Add to the Stability of “Hybrid” Plate Constructs in Osteoporotic Bone?

Andy L. Freeman, MSME1 (n); Paul Tornetta III, MD2 (e-Smith+Nephew);
Andrew Schmidt, MD3 (e-Smith+Nephew); Joan Bechtold, PhD1 (n);
William Ricci, MD4 (e-Smith+Nephew); Mark Flemming, MD3 (n);
1Gustilo Medical Education Center, Minneapolis, Minnesota, USA;
2Boston University Medical Center, Boston, Massachusetts, USA;
3Hennepin County Medical Center, Minneapolis, Minnesota, USA;
4Washington University, St. Louis, Missouri, USA


Fri., 10/19/07 Basic Science, Paper #44, 4:54 pm OTA-2007

Comparison of Negative-Pressure Dressing and Standard Dressing in a Contaminated Open Fracture Model

MAJ Steven J. Lalliss, MD (n); CPT Joanna G. Branstetter, MD (n); Joseph C. Wenke, PhD (n);
US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA


Fri., 10/19/07 Basic Science, Paper #45, 5:00 pm OTA-2007

Δ Time is Muscle: An Experimental Model of Compartment Syndrome

Abdel Lawendy, MD1; David Sanders, MD, MSc2; Aurelia Bihari, MSc3; Neil Parry, MD2; Daryl Gray, MD2; Amit Badhwar, PhD3;
(all authors: a-OTA/Foundation for Orthopaedic Trauma Resident Research Grant);
1University of Western Ontario, London, Ontario, Canada;
2Victoria Hospital, Lawson Health Research Institute, University of Western Ontario,
London, Ontario, Canada;
3Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada


If noted, the author indicates something of value received. The codes are identified as a-research or institutional support; b-miscellaneous funding; c-royalties; d-stock options; e-consultant or employee; n-no conflicts disclosed, and *disclosure not available at time of printing.

• The FDA has not cleared this drug and/or medical device for the use described in this presentation   (i.e., the drug or medical device is being discussed for an “off label” use).  ◆FDA information not available at time of printing.