| TITLE: | Brief communication: effects of diagnostic irradiation during pregnancy on head circumference at birth. | ||||||
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| AUTHORS: | Bohnen NI; Ragozzino MW; Kurland LT | ||||||
| AUTHOR AFFILIATION: | Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA. | ||||||
| SOURCE: | Int J Neurosci 1996 Nov;87(3-4):175-80 | ||||||
| CITATION IDS: | PMID: 9003977 UI: 97157698 | ||||||
| ABSTRACT: | A historical cohort study was carried out to evaluate the effects in utero medical ionizing radiation on head circumference at birth. The nature of medical practice in Rochester, Minnesota, and the Mayo Clinic medical records linkage system enabled us to provide accurate estimates of medical radiation absorbed dose in 9,793 pregnancies of 2,980 women pregnant in Rochester between 1917 through 1973. Data were controlled for sex of the fetus, duration of pregnancy and congenital head abnormalities. It was found that medical ionizing radiation in the second and third trimesters of more than 300 mrad were related to significantly decreased head circumference. There was no significant effect of radiation exposure in the first trimester or periconceptional period. Medical ionizing radiation in the second and third trimesters of more than 300 mrad is related to a significant yet minimal, decreasing head circumference at birth. Maximum effects were seen during the midgestational and second trimester periods. | ||||||
| MAIN MESH HEADINGS: | Head/*radiation effects | ||||||
| ADDITIONAL MESH HEADINGS: | Cephalometry Cohort Studies Comparative Study Female Fetal Diseases/radiography Fetus/radiation effects Head/anatomy & histology Head/embryology Human Infant, Newborn Male Ovary/radiation effects Pregnancy Pregnancy Complications/radiography Pregnancy Trimester, Second Pregnancy Trimester, Third Radiation Dosage Radiography/adverse effects Radiotherapy/adverse effects Retrospective Studies Support, U.S. Gov't, Non-P.H.S. | ||||||
| PUBLICATION TYPES: | JOURNAL ARTICLE | ||||||
| LANGUAGES: | Eng | ||||||